In Belize, the Thomas Vincent Ramos Highway takes up where the Hummingbird Highway ends and runs from Dangriga to Punta Gorda. It is entirely paved, with the completion of a 10-mile segment between Golden Stream and Big Falls circa 2008–09. The T.V. Ramos Highway provides important access to a number of Mayan ruins and natural areas. The ancient Mayan sites of Nim Li Punit and Lubaantun are each situated a few miles west of the highway in southern Belize. The Cockscomb Basin Wildlife Sanctuary is several miles west of the highway in south-central Belize.
In 2011, a project was initiated, and complete by 2015, to extend the Southern Highway 21.4 mi/34.5 km to Jalacte in southwestern Belize.
On September 30, 2020 the Southern Highway was renamed to Thomas Vincent Ramos Highway. It was named after Thomas Vincent Ramos, the creator of Garifuna Settlement Day.
Junction list
| Stann Creek | 0.0 | 0.0 | Hummingbird Highway | Elevation, 21 m |
| 10.0 | 16.1 | Road into Commerce Bight | Elevation, 23 m | |
| 12.3 | 19.8 | Road into Hopkins | Elevation, 19 m | |
| 19.3 | 31.1 | Placencia Road –Placencia, Riversdale, Seine Bight | Elevation, 30 metres | |
| 43.8 | 70.5 | Turnoff to Monkey River Town | Elevation, 20 m | |
| Toledo District | 77.4 | 124.6 | Turnoff to Silver Creek, San Miguel, San Pedro Columbia | Elevation, 29 m |
| 83.1 | 133.7 | Junction: road southeast to Toledo District – Punta Gorda; northwest along Jalacte road to Jimmy Cut, Pueblo Viejo, Blue Creek, Aguacate, Otoxha and Dolores | Elevation, 24 metres | |
| 86.1 | 138.6 | Machaca Forest Station | Elevation, 34 m | |
| 88.9 | 143.0 | Road to Piebra, Barranco, Conejo, Crique Sarco | Elevation, 15 m | |
| 92.1 | 148.3 | West access road – Punta Gorda | Elevation, 24 m | |
| 97.1 | 156.2 | West access road | Terminus of highway; elevation, 7 metres |
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